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Effects of Other Drugs on VIAGRA Sildenafil metabolism is principally mediated by CYP3A4 (big route) and CYP2C9 (small route). Therefore, inhibitors of those isoenzymes may minimize sildenafil clearance and inducers of such isoenzymes may boost sildenafil clearance.Sildenafil is likewise from time to time utilized to deal with pulmonary hypertensio
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